Commissioned by a citizens' vote against the plague, the church was started in 1530 and built in several phases until 1561, as evidenced by the coats of arms of the Venetian rectors Giacomo Salomon (1659) on the left column and Pietro Loredan (1561) under the statue of Saint Roch placed at the center of the façade.
It was officiated by the Capuchins between 1605 and 1769 together with the adjacent convent, which, after its closure during the Napoleonic era in 1806, passed to the state and was purchased by Countess Elisabetta Agosti in 1856. After the complex was renovated, the church was reopened for worship in 1860, and the convent was transformed into an orphanage by Don Antonio Sperti.
The institute was then entrusted to the Salesians along with the church from 1924 to 1957. Outside, under the portico, two frescoes dated 1564 depicting the Trinity and Saints Roch and Sebastian on the right, and Saints Cosmas and Damian on the left. Inside, behind the main altar, a sixteenth-century copy of the Assumption by Titian, the "Ecstasy of St. Francis" by the Belluno artist Gaspare Diziani (1689-1767), a large wooden tabernacle by Valentino Panciera Besarel (1829-1902), and other paintings by Luigi Speranza (1819-1879), Luigi Cima (1860-1944), and Antonio Duodo.
